Name :
Anti-PDL1 antibody(23D8), IgG1 Chimeric mAb
Uniprot ID :
Q9NZQ7
Common Name :
Synonyms :
PD-L1;CD274;B7-H1;PDCD1L1;PDCD1LG1
Application :
WB
Recommended Dilutions :
WB 1:1000
Formulation &Reconstitution :
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Host Species :
Rabbit
IgG type :
Rabbit/Human Fc chimeric IgG1
Reactivity :
Human
Target :
PDL1
Description :
Anti-PDL1 antibody(23D8), IgG1 Chimeric mAb
Delivery :
In Stock
Storage&Shipping :
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background :
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Usage :
Research use only
Related websites: https://www.medchemexpress.com/antibodies.html
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