Pinus pinea L., a long-lived Mediterranean conifer, exemplifies the paradox of high phenotypic plasticity coupled with extremely low genetic diversity. This study focuses on uncovering the genome-wide landscape of cytosine…
Schizophrenia is a complex neuropsychiatric disorder affecting approximately 1% of the global population. Its onset typically occurs during late adolescence or early adulthood, with symptoms influenced by both genetic predisposition…
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with limited treatment options for patients who do not harbor EGFR mutations. Despite the success of epidermal growth…
A 6-year-old boy from Yokohama, Japan, presented to the pediatric emergency department with acute abdominal colic, recurrent bilious vomiting, and a low-grade fever of 38.0°C. He had no prior history…
Lignosus rhinocerotis, commonly known as the tiger’s milk mushroom, is a medicinal fungus traditionally used in Southeast Asia for its health-promoting properties. Despite its therapeutic potential, the natural supply of…
Staphylococcus aureus is a leading cause of osteomyelitis, a severe bone infection characterized by inflammation and destruction of bone tissue. While healthcare-associated MRSA (HA-MRSA) has long been recognized as a…
PK-THPP and A1899 are potent antagonists of the TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channels, which mediate a constitutive background potassium conductance that is sensitive to acidic pH…
Hepatitis C virus (HCV) infection remains a significant public health concern, particularly in Japan, where over 880,000 individuals are estimated to be chronically infected. As breast cancer is the most…
Hepatocellular carcinoma (HCC) remains a major global health challenge, particularly in patients with chronic hepatitis C virus (HCV) infection. Despite advances in antiviral therapy, a significant proportion of individuals with…
Brown adipose tissue (BAT) has emerged as a pivotal player in the regulation of human body weight due to its unique capacity for thermogenesis. Unlike white adipose tissue (WAT), which…