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Transfer of cosmid DNA from Escherichia coli to Saccharopolyspora spinosa: effects
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EditorialCan selective inhibitors of cyclic guanosine monophosphate (cGMP)-specific phosphadiesterase variety 5 (PDE five) offer you protection against contrast induced nephropathySameh K. MorcosDiagnostic Imaging, University of Sheffield, Sheffield, UK Correspondence to: Sameh K. Morcos. Division of X-ray, Northern Common Hospital, Herries Road, Sheffield S5 7AU, UK. E mail: [email protected]: Parenchymal hypoxia inside the renal outer medulla plays an important function in the pathogenesis of contrast induced nephropathy (CIN). Nitric oxide (NO) is crucial for medullary oxygenation by enhancing regional blood flow. Augmenting the impact of NO within the renal medulla by the usage of selective inhibitors of cyclic guanosine monophosphate (cGMP)-specific phosphadiesterase variety five (PDE five) such as sildenafil (ViagraTM), vardenafil (LevitraTM) or tadalafil (CialisTM) could lower the severity with the hypoxic insult induced by the contrast medium and minimize the danger of CIN. Prophylactic administration of among these drugs particularly t.