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ted. More file 10. Enriched terms in up-regulated genes amongst Supplemented Infected vs Control Infected. Extra file 11. Enriched terms inside the list of differentially upregulated genes involving the groups Control Infected vs Supplemented Infected. Added file 12. Average liveweight and age (common deviation) for each group at the starting and end with the experiment. Further file 13. Composition of your manage protein and supplemented protein diets. Additional file 14. Bromatological composition (g kg-1 of dry matter at one hundred ) and power (MJ) of the diets’ components. Extra file 15. Bromatological evaluation with the eating plan. More file 16. List of ovarian RNA samples, their concentration, 260/280 and 260/230 absorbance ratios. Additional file 17. EM estimation algorithm process. Further file 18. Statistical methodology used in the Enrichment evaluation. More file 19. Protein Network analysis. Acknowledgements Not applicable. Arrive recommendations statement This study was carried out in compliance with the ARRIVE suggestions. Authors’ contributions P.S.H. carried out the in vivo and laboratory experiments, analysed the information and wrote the manuscript. C.M.S.C. carried out the in vivo and laboratory experiments. R.C.L. performed the statistical analyses, assisted with manuscript writing and revision. D.G.C. helped with qPCR arranging and qPCR information evaluation. L.M.K. cultivated and offered the Haemonchus contortus larvae. S.M.T. assisted in the organizing of experiments. H. L. elaborated the study style and arranging, assisted inside the manuscript revision. The author(s) study and authorized the final manuscript. Author’s information Paula Suarez-Henriques can be a veterinary surgeon with a Master in Animal Science along with a Doctorate in Animal Science. She obtained each degrees Nav1.4 supplier within the last six years in the SIRT1 manufacturer University of S Paulo in Brazil. In July 2020, she presented a part of her doctorate investigation at the Society for the Study of Reproduction virtual meeting. Ahead of that, she worked as a veterinarian clinician and also a analysis assistant in laboratories studying molecular pathology of breast cancers, cell and molecular biology in mammary gland improvement, and multiple myeloma resistance to alkylating agents. Funding We thank the National Council for Scientific and Technological Research -(CNPq – Brazil) and CAPES for the monetary support with Paula SuarezHenriques’ PhD studentship bursary number 141846/2017 and, for funding the charges of reagents and equipment important for the accomplishment of this research project, with course of action numbers CNPq 311008/2016-0 and CNPq 420373/2016. We also thank S Paulo Investigation Assistance FoundationSupplementary InformationThe on line version includes supplementary material obtainable at doi. org/10.1186/s12917-021-03020-7. Additional file 1: Table S1. RNA sequencing data top quality summary. Extra file two: Table S2. Quantity of sequences and Sequencing depth generated by RNA sequencing.Suarez-Henriques et al. BMC Veterinary Investigation(2021) 17:Page 22 of(FAPESP) procedure numbers 2017/50451 and 2017/18086-0, for further funding for reagents. Availability of information and supplies The datasets used and/or analysed in the course of the current study are accessible within the Added files. The files which can be not in this section may be provided under reasonable request to Dr. Helder Louvandini e-mail address: [email protected] approval This investigation project, with its protocol and procedures employed, have been eth