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Conceptual structure evaluation working with MCA (Figure 3) showed that most reports on ENDS and HTPs are grouped into 3 categories: in vitro evaluation, which incorporates terms like cell-line and epithelial cells; animal models, which includes terms for example mice and lung; and human research, such as males, females, and young adults. We make use of these categories to group the findings within the revised articles.Int. J. FP Agonist manufacturer Environ. Res. Public Wellness 2021, 18,Int. J. Environ. Res. Public Overall health 2021, 18, x3 of3 ofprocess followed the PRISMA guidelines (Preferred Reporting Products for Systematic critiques four of 14 Int. J.Figure 1. The short article selection18, x Environ. Res. 1. The report selection approach followedthe PRISMAguidelines (Preferred Reporting Things for Systematic critiques Figure Public Overall health 2021, and Meta-Analyses) [19]. and Meta-Analyses) [19].The bibliometric evaluation discovered three primary D3 Receptor Agonist Formulation hierarchical topics. We grouped the key phrases into three clusters and ran the MCA analysis with 20 words across all articles out there to search for relationships in more than 80 of your literature reviewed (Figure two). The conceptual structure analysis utilizing MCA (Figure 3) showed that most reports on ENDS and HTPs are grouped into three categories: in vitro evaluation, which incorporates terms for instance cell-line and epithelial cells; animal models, which contains terms such as mice and lung; and human studies, which includes males, females, and young adults. We utilize these categories to group the findings in the revised articles.Figure 2. Evaluation of the conceptual structure by topic dendrogram determined three hierarchical categories with the key phrases Figure two. Evaluation from the conceptual structure by subject dendrogram determined three hierarchical categories of your keywords inincluded within the articles analyzed. Green = human studies; blue = animal models; red = in vitro studies. cluded in the articles analyzed. Green = human studies; blue = animal models; red = in vitro studies.Figure two. Analysis with the conceptual structure by subject dendrogram determined 3 hierarchical categories with the keywords integrated inside the articles analyzed. Green = human research; blue = animal models; red = in vitro research.Int. J. Environ. Res. Public Health 2021, 18,4 ofFigure three. Conceptual structure obtained by many correspondence analysis with the keyword phrases analyzed. analyzed. Figure three. Conceptual structure mapmap obtained by many correspondence analysis on the keywords and phrases Dim = diDim = dimension; Green research; research; blue models; models; red = in vitro mension; Green = human= humanblue = animal = animalred = in vitro studies. studies.3.1. In Vitro Models three.1. In Vitro Models Most studies in vitro utilize immortal cell lines from distinct components on the lung Most studies in vitro use immortal cell lines from various parts with the lung (bron(bronchial epithelium, lung fibroblast); this is a extensively made use of model due to its low chialand convenience. fibroblast);this model from time to time model as a result of its low price and price epithelium, lung However, this is a extensively applied provides varying final results, as some comfort. Even so, this modelin immortalization tend to interfere with a few of the of your cellular pathways involved at times gives varying outcomes, as biomarkers cellular pathways involved in immortalization have a tendency toMore recent research have opted for released in inflammation and DNA harm [224]. interfere with biomarkers released in inflammation and DNA harm [224]. Moreobtained from healt.