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A selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM
Reference:
Ma A, et al. Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8. J Med Chem. 2014 Aug 14;57(15):6822-33.
CAS No: 1620401-82-2
Chemical Name: 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
| Molecular Formula | C23H35N5O2 |
| Molecular Weight | 413.56 |
| CAS Numbers | 1620401-82-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | more than 25 mg/mL/DMSO |
| Purity | 98% by HPLC |
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18506595