Product Name :
Novobiocin Sodium
Description:
Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity.
CAS:
1476-53-5
Molecular Weight:
634.61
Formula:
C31H35N2NaO11
Chemical Name:
(3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2-oxo-2H-chromen-7-yloxy)-3-methoxy-2,2-dimethyloxan-4-yl carbamate sodium
Smiles :
[Na+].CC(C)=CCC1=CC(=CC=C1[O-])C(=O)NC1C(=O)OC2=C(C=CC(O[C@@H]3OC(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@H]3O)=C2C)C=1O
InChiKey:
WWPRGAYLRGSOSU-RNROJPEYSA-M
InChi :
InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q;+1/p-1/t23-,25+,26-,29-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity.|Product information|CAS Number: 1476-53-5|Molecular Weight: 634.61|Formula: C31H35N2NaO11|Synonym:|Albamycin|Cathomycin|Chemical Name: (3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2-oxo-2H-chromen-7-yloxy)-3-methoxy-2,2-dimethyloxan-4-yl carbamate sodium|Smiles: [Na+].CC(C)=CCC1=CC(=CC=C1[O-])C(=O)NC1C(=O)OC2=C(C=CC(O[C@@H]3OC(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@H]3O)=C2C)C=1O|InChiKey: WWPRGAYLRGSOSU-RNROJPEYSA-M|InChi: InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q;+1/p-1/t23-,25+,26-,29-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 83.33 mg/mL (131.31 mM; Need ultrasonic) DMSO : ≥ 30 mg/mL (47.27 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.Encorafenib In Vitro |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.4-Thiouridine Biological Activity |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Novobiocin Sodium (0.PMID:31608713 3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2. Novobiocin (0-500 μM; 15-hours) is against wild type, lptB1, lptB1(R144H), and efflux pump-deficient ∆tolC strains with IC50 values of 62.5-125 μM; 0.5 μM; 62.5-125 μM; and 2 μM, respectively.|References:|Bhatia S, et al. Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.Blood. 2018 Jul 19;132(3):307-320.Burlison JA, et al. Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.J Am Chem Soc. 2006 Dec 6;128(48):15529-36.Products are for research use only. Not for human use.|