Ascomycin (FK520)
Band: www.medchemexpress.com
Analog of ; binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity
CAS No:104987-12-4
Chemical Name:(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
| Molecular Formula | C43H69NO12 |
| Molecular Weight | 792.01 |
| CAS Numbers | 104987-12-4 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | 50 mMol in DMSO or Ethanol |
| Purity | 98% by HPLC |
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18539529