Diphtheria Toxoid Control Antigen BA130VS

Additional Information:
targetDiphtheria Toxoid|species reactivityCorynebacterium diphtheriae|applicationsELISA|assay typeIndirect & quantitative|available size1 mg|Diphtheria Toxoid Control Antigen BA130VSkitAssay typeImmunoassayResearch areaInfectious DiseaseStorageStore at -65C. Avoid freeze/thaw cycles. Sonicate before use.FormliquidAssociated productsDiphtheria Toxoid Control Antigen (BA130VS)Diphtheria IgG Control Serum (BC130G)Corynebacteria dyptheriae IgG ELISA Kit (ESR130G)target relevanceOrganismCorynebacterium diphtheriaeStructure and strainsCorynebacterium diphtheriae is the pathogenic bacterium that causes diphtheria. The bacteria are usually harmless unless they are infected by a bacteriophage that carries a gene that gives rise to a toxin. This toxin causes the disease. Diphtheria is caused by the adhesion and infiltration of the bacteria into the mucosal layers of the body, primarily affecting the respiratory tract and the subsequent release of an endotoxin. The toxin has a localized effect on skin lesions, as well as a metastatic, proteolytic effects on other organ systems in severe infections.DiseaseDiphtheria is a globally distributed infectious disease, that is mainly transmitted by droplet infection and in rare cases by smear infection. The incubation time is usually two to five days. In temperate climate zones, clinical symptoms of diphtheria mainly affect the respiratory tract. A primary infection can involve the tonsillar pharyngeal region or cause laryngeal, nasal or tracheobronchial primary infection in sequential order. The most important complications are myocarditis and polyneuritis. In 5 to 25% of cases, diphtheria can take a lethal course due to respiratory obstruction or coronary failure. As a consequence of extensive immunization programs, cases of this once common disease have declined considerably. Nevertheless, an increasing number of regional epidemics occur in countries with low vaccination coverage.Detection and diagnosisDiphtheria is caused by Corynebacterium diphtheriae. The diphtheria toxin is responsible for pathogenicity. For practical and economic reasons a passive hemagglutination test was used for the detection of diphtheria antitoxin in human serum samples. It is specified in international units per milliliter (IU/ml). However, ELISA techniques have been increasingly utilized in recent years, due to the possibility of standardization and the ability for automated processing. Adjusted to international reference preparations, the IgG antibody activity measured by the SERION ELISA classic Diphtheria IgG test is expressed in IU/ml. The control of vaccination success as well as the determination of the immune status prior to immunization in order to prevent hyperimmune reactions plays an increasing role in routine laboratories. In recent years, different studies reported a high rate of unimmunized individuals among the adult population. The serological demonstration of the anti-diphtheria toxin IgG antibody activity provides a basis for the necessity of vaccination.|