Sat. Apr 11th, 2026

SMARt-420 (BDM41420)

Band: www.medchemexpress.com

The first-in-class activator of a cryptic alternative bioactivation pathway of ethionamide in M. tuberculosis, circumventing the classic activation pathway, fully reversing ethionamide-acquired resistance and clearing ethionamide-resistant infection in mice, also increasing the basal sensitivity of bacteria to ethionamide

Chemical Name: BDM41420; 4,4,4-Trifluoro-1-(3-phenyl-1-oxa-2,8-diaza-spiro[4.5]dec-2-en-8-yl)-butan-1-one

ACY-1222

Molecular Formula C17H19F3N2O2
Molecular Weight 340.34
CAS Numbers N/A
Storage Condition 0°C (short term), -20°C (long term), desiccated
Solubility DMSO
Purity 98% by HPLC

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18550847

Related Post