Somru Bioscience is an rising biotechnology organization committed to establishing breakthrough antibody know-how for research, diagnostic and therapeutic applications. The corporation utilizes a exclusive and proprietary Somru™ engineering which creates antibodies with remarkable binding affinity and bioactivity in a huge selection of organic assays in a small time period of time. Somru BioScience Inc.65 Watts Ave. West Royalty Industrial Park Charlottetown Prince Edward Island, C1E 2B7 Canada
The notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. The notch signaling pathway is important for cell-cell communication, which involves gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life.