Cture in eNOS-deficient mice recovering from purchase PHCCC neonatal hypoxia. Am J Physiol Lung Cell Mol Physiol 291: L119127. 21. Bland RD, Albertine KH, Carlton DP, MacRitchie AJ Inhaled nitric oxide effects on lung 80-49-9 structure and function in chronically ventilated preterm lambs. Am J Respir Crit Care Med 172: 899906. 22. McCurnin DC, Pierce RA, Chang LY, Gibson LL, Osborne-Lawrence S, et al. Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition inside a baboon model of neonatal chronic lung illness. Am J Physiol Lung Cell Mol Physiol 288: L450459. 23. Soll RF Inhaled nitric oxide for respiratory failure in preterm infants. Neonatology 102: 251253. 24. Faller S, Zimmermann KK, Strosing KM, Engelstaedter H, Buerkle H, et al. Inhaled hydrogen sulfide protects against lipopolysaccharide-induced acute lung injury in mice. Med Gas Res two: 26. 25. Faller S, Ryter SW, Choi AM, Loop T, Schmidt R, et al. Inhaled hydrogen sulfide protects against ventilator-induced lung injury. Anesthesiology 113: 104115. 26. Francis RC, Vaporidi K, Bloch KD, Ichinose F, Zapol WM Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology 115: 10121021. 9 Hydrogen Sulfide and Lung Repair 27. McGrath-Morrow S, Lauer T, Yee M, Neptune E, Podowski M, et al. Nrf2 increases survival and attenuates alveolar development inhibition in neonatal mice exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol 296: L565573. 28. Cho HY, van Houten B, Wang X, Miller-DeGraff L, Fostel J, et al. Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice. Antioxid Redox Signal 17: 10661082. 29. Jankov RP, Kantores C, Belcastro R, Yi M, Tanswell AK Endothelin-1 inhibits apoptosis of pulmonary arterial smooth muscle within the neonatal rat. Pediatr Res 60: 245251. 30. Meng QH, Yang G, Yang W, Jiang B, Wu L, et al. Protective impact of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries. Am J Pathol 170: 14061414. 31. Wang T, Wang L, Zaidi SR, Sammani S, Siegler J, et al. Hydrogen Sulfide Attenuates Particulate Matter-Induced Human Lung Endothelial Barrier Disruption via Combined Reactive Oxygen Species Scavenging and Akt Activation. Am J Respir Cell Mol Biol 47: 491496. 32. Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, et al. The novel proangiogenic impact of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovasc Res 76: 2940. 33. Zheng ZZ, Liu ZX Activation from the phosphatidylinositol 3-kinase/ protein kinase Akt pathway mediates CD151-induced endothelial cell proliferation and cell migration. Int J Biochem Cell Biol 39: 340348. 34. Singleton PA, Chatchavalvanich S, Fu P, Xing J, Birukova AA, et al. Aktmediated transactivation on the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. Circ Res 104: 978986. 35. Michan S, Sinclair D Sirtuins in mammals: insights into their biological function. Biochem J 404: 113. 36. Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 177: 861 870. 37. Freeman BA, Crapo JD Hyperoxia increases oxygen radical production 15857111 in rat lungs and lung mitochondria. J Biol Chem 256: 1098610992. 38. Esteve JM, Mompo J, Garcia de la Asuncion J, Sastre J, Asensi M, et al. Oxidative harm to mitochondrial.Cture in eNOS-deficient mice recovering from neonatal hypoxia. Am J Physiol Lung Cell Mol Physiol 291: L119127. 21. Bland RD, Albertine KH, Carlton DP, MacRitchie AJ Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs. Am J Respir Crit Care Med 172: 899906. 22. McCurnin DC, Pierce RA, Chang LY, Gibson LL, Osborne-Lawrence S, et al. Inhaled NO improves early pulmonary function and modifies lung development and elastin deposition in a baboon model of neonatal chronic lung illness. Am J Physiol Lung Cell Mol Physiol 288: L450459. 23. Soll RF Inhaled nitric oxide for respiratory failure in preterm infants. Neonatology 102: 251253. 24. Faller S, Zimmermann KK, Strosing KM, Engelstaedter H, Buerkle H, et al. Inhaled hydrogen sulfide protects against lipopolysaccharide-induced acute lung injury in mice. Med Gas Res two: 26. 25. Faller S, Ryter SW, Choi AM, Loop T, Schmidt R, et al. Inhaled hydrogen sulfide protects against ventilator-induced lung injury. Anesthesiology 113: 104115. 26. Francis RC, Vaporidi K, Bloch KD, Ichinose F, Zapol WM Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology 115: 10121021. 9 Hydrogen Sulfide and Lung Repair 27. McGrath-Morrow S, Lauer T, Yee M, Neptune E, Podowski M, et al. Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol 296: L565573. 28. Cho HY, van Houten B, Wang X, Miller-DeGraff L, Fostel J, et al. Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice. Antioxid Redox Signal 17: 10661082. 29. Jankov RP, Kantores C, Belcastro R, Yi M, Tanswell AK Endothelin-1 inhibits apoptosis of pulmonary arterial smooth muscle in the neonatal rat. Pediatr Res 60: 245251. 30. Meng QH, Yang G, Yang W, Jiang B, Wu L, et al. Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries. Am J Pathol 170: 14061414. 31. Wang T, Wang L, Zaidi SR, Sammani S, Siegler J, et al. Hydrogen Sulfide Attenuates Particulate Matter-Induced Human Lung Endothelial Barrier Disruption by way of Combined Reactive Oxygen Species Scavenging and Akt Activation. Am J Respir Cell Mol Biol 47: 491496. 32. Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, et al. The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovasc Res 76: 2940. 33. Zheng ZZ, Liu ZX Activation with the phosphatidylinositol 3-kinase/ protein kinase Akt pathway mediates CD151-induced endothelial cell proliferation and cell migration. Int J Biochem Cell Biol 39: 340348. 34. Singleton PA, Chatchavalvanich S, Fu P, Xing J, Birukova AA, et al. Aktmediated transactivation from the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. Circ Res 104: 978986. 35. Michan S, Sinclair D Sirtuins in mammals: insights into their biological function. Biochem J 404: 113. 36. Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of sufferers with chronic obstructive pulmonary illness. Am J Respir Crit Care Med 177: 861 870. 37. Freeman BA, Crapo JD Hyperoxia increases oxygen radical production 15857111 in rat lungs and lung mitochondria. J Biol Chem 256: 1098610992. 38. Esteve JM, Mompo J, Garcia de la Asuncion J, Sastre J, Asensi M, et al. Oxidative harm to mitochondrial.